The efficacy of the combination of radiofrequency ablation and endoscopic metal stent in the treatment of 44 patients with unresectable cholangiocarcinoma / 中华消化杂志

Objective:To explore the efficacy of the combination of radiofrequency ablation(RFA) and endoscopic metal stent in the treatment of patients with unresectable cholangiocarcinoma.Methods:From January 3, 2012 to June 30, 2019, at the Department of Endoscopic of the Third Affiliated Hospital of Naval Medical University, the clinical data of 44 patients with unresectable cholangiocarcinoma who were treated by the combination of RFA and endoscopic metal stent were retrospectively collected, which included age, gender, location of cholangiocarcinoma(hilar cholangiocarcinoma and distal cholangiocarcinoma), etc. Postoperative evaluation was conducted based on the follow-up, including clinical success rate, postoperative complication rate, time of stent patency and overall survival time (OS). The Kaplan-Meier method and log-rank test were used to analyze the difference of OS between patients with hilar cholangiocarcinoma and distal cholangiocarcinoma. Mann-Whitney U test was used for statistical analysis. Results:The age of the 44 patients with cholangiocarcinoma was (70.3±11.6) years old, with 20 males (45.5%). There were 22 patients (50.0%) with hilar cholangiocarcinoma and 22 patients (50.0%) with distal cholangiocarcinoma. The clinical success rate of 44 patients was 93.2%(41/44). A total of 5 patients(11.4%) had postoperative complications, which were all improved by appropriate treatment. The median time of follow-up of the 44 patient was 9.2 months(ranged from 3.1 to 57.6 months), the median time of stent patency was 7.0 months (ranged from 5.8 to 8.2 months). Thirty-two patients (72.7%) died during the follow-up, and the median OS was 10.9 months(ranged from 9.0 to 12.8 months). The median OS of patients with hilar cholangiocarcinoma was 7.8 months(ranged from 4.6 to 11.0 months) and that of patients with distal cholangiocarcinoma was 12.5 months(ranged from 5.7 to 19.4 months), and there was no statistically significant difference( P>0.05). Conclusion:RFA combined with endoscopic metal stent is safe and effective in the treatment of patients with unresectable cholangiocarcinoma.

Influence of effective liver drainage volume on overall survival in patients with malignant hilar biliary obstruction: a multicenter study / 中华消化内镜杂志

Objective:To investigate the influence of liver drainage volume on overall survival time in patients with unresectable malignant hilar bile duct obstruction.Methods:Data of 633 patients with unresectable malignant hilar bile duct obstruction (BismuthⅡ-Ⅳ) who underwent endoscopic stent drainage in 3 endoscopy centers from January 2002 to May 2019 were retrospectively analyzed. Main observation indicators included clinical success rate, stent patency, overall survival, the effective liver drainage volume, and complication incidence.Results:The clinical success rates of patients with liver drainage volume <30%, 30%-50%, and >50% were 56.8% (25/44), 77.3% (201/260) and 84.2% (277/329) respectively. The incidences of early cholangitis were 31.8% (14/44), 18.8% (49/260) and 16.1% (53/329). The median stent patency time was 4.5 (95% CI: 1.8-7.2) months, 5.6 (95% CI: 5.0-6.2) months and 6.6 (95% CI: 5.2-8.0) months. The overall survival time was 2.4 (95% CI: 1.8-3.0) months, 4.0 (95% CI: 3.4-4.6) months and 4.9 (95% CI:4.4-5.4) months, respectively. The clinical success rate ( χ 2=8.28, P=0.012), median stent patency period ( χ 2=18.87, P=0.015) and overall survival time ( χ 2=6.93, P=0.024) of 30%-50% liver drainage volume group were significantly higher than those of <30% group. Further multivariate cox regression analysis showed that the disease type (hepatocellular carcinoma VS hilar cholangiocarcinoma: HR=1.50, 95% CI:1.18-1.91, P=0.001; gallbladder carcinoma VS hilar cholangiocarcinoma: HR=1.45, 95% CI:1.14-1.85, P=0.002; metastatic cholangiocarcinoma VS hilar cholangiocarcinoma: HR=1.48, 95% CI:1.08-2.04, P=0.015), bilirubin level >200 μmol/L ( HR=1.35, 95% CI:1.14-1.60, P<0.001),metal stents ( HR=0.67, 95% CI:0.56-0.79, P<0.001), liver drainage volume (volume 30%-50% VS <30%: HR=0.64, 95% CI: 0.45-0.90, P=0.010; volume>50% VS <30%: HR=0.58, 95% CI:0.41-0.81, P=0.002) and anti-tumor therapy ( HR=0.51, 95% CI:0.42-0.61, P<0.001) were independent predictors for overall survival time of patients with unresectable malignant hilar bile duct obstruction. Conclusion:When endoscopic stent drainage is performed for patients with unresectable malignant hilar bile duct obstruction, at least 30% liver volume is required for better overall survival. In addition, the use of metal stent drainage and anti-tumor therapy may increase survival benefits.

Application value of different metal stents placement position in endoscopic drainage of malig-nant hilar bile duct obstruction: a multicenter study / 中华消化外科杂志

Objective:To investigate the application value of different metal stents place-ment position in endoscopic drainage of malignant hilar bile duct obstruction.Methods:The retro-spective cohort study was conducted. The clinicopathological data of 300 patients with malignant hilar bile duct obstruction who were admitted to 3 medical centers, including 216 patients in the Third Affiliated Hospital of Naval Medical University, 48 patients in the Xijing Hospital of Air Force Medical University, 36 patients in the First People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, from January 2012 to January 2019 were collected. There were 164 males and 136 females, aged (67±12)years. All patients were determined to be unresectable by multidisciplinary consultation and underwent endoscopic retrograde cholangiopancreatography. Observation indicators: (1) clinicopathological features of patients; (2) follow-up; (3) analysis of influencing factors for patency time of metal biliary stents and overall survival time of patients. Follow-up was conducted using outpatient examination and telephone interview to detect patency of metal biliary stents and survival of patients up to July 2019 or death of patients. Measurement data with normal distribution were represented as Mean± SD, and comparison between groups was conducted using the independent sample t test. Measurement data with skewed distribution were represented as M( Q1, Q3), and comparison between groups was conducted using the Mann-Whitney U test. Count data were expressed as absolute numbers or percentages, and comparison between groups was conducted using the chi-square test or Fisher exact probability. Comparison of ordinal data was conducted using the rank sum test. Kaplan-Meier method was used to calculate survival rates and draw survival curves, and Log-Rank test was used to conduct survival analysis. COX regression model was used for univariate and multivariate analyses. Factors with P<0.1 in univariate analysis were included in multivariate analysis. Results:(1) Clinicopathological features of patients. Of the 300 patients, 163 cases underwent endoscopic drainage with at least one metal biliary stent' distal portion crossing the duodenal main papilla (hereinafter referred to as crossing papilla), and 137 cases underwent endoscopic drainage with no metal biliary stent' distal portion crossing the duodenal main papilla (hereinafter referred to as no crossing papilla). Age, disease type (hilar cholangiocarcinoma, hepatocellular carcinoma, intrahepatic cholangio-carcinoma, gallbladder carcinoma, metastatic cholangiocarcinoma), metal biliary stents type (unilateral metal biliary stent, bilateral metal biliary stents) of patients with crossing papilla were (68±13)years, 95, 8, 11, 31, 18, 63, 100, respectively. The above indicators of patients with no crossing papilla were (64±12)years, 63, 22, 20, 23, 9, 126, 11, respectively. There were significant differences in the above indicators between patients with crossing papilla and patients with no crossing papilla ( t=2.70, χ2=17.69, 90.79, P<0.05). (2) Follow-up. All the 300 patients were followed up for 5.4(3.1,9.3)months. The patency time of metal biliary stents was 9.0(8.2,9.8)months and 6.4(4.8,8.0)months of patients with crossing papilla and patients with no crossing papilla, showing a significant difference between them ( χ2=8.23, P<0.05). The overall survival time was 5.5(4.2,6.8)months and 5.5(4.3,6.8)months of patients with crossing papilla and patients with no crossing papilla, showing no significant difference between them ( χ2=0.28, P>0.05). (3) Analysis of influencing factors for patency time of metal biliary stents and overall survival time of patients. Results of univariate analysis showed that type of metal biliary stents and the placement position of metal biliary stents were related factors affecting the patency time of metal biliary stents [ hazard ratio( HR)=0.44, 0.60, 95% confidence intervals as 0.30?0.64, 0.42?0.85, P<0.05]. Results of multi-variate analysis showed that bilateral metal biliary stents was an independent protective factor for the patency time of metal biliary stents ( HR=0.46, 95% confidence interval as 0.29?0.72, P<0.05). Results of univariate analysis showed that disease type (intrahepatic cholangiocarcinoma versus hilar cholangiocarcinoma), preoperative serum total bilirubin, type of metal biliary stents, anti-tumor therapy were related factors affecting the overall survival time of patients ( HR=1.05, 1.43, 0.72, 0.61, 95% confidence intervals as 0.70?1.57, 1.12?1.83, 0.55?0.92, 0.47?0.81, P<0.05). Results of multi-variate analysis showed that age >60 years, disease type as hepatocellular carcinoma, preoperative serum total bilirubin >200 μmol/L were independent risk factors for the overall survival time of patients ( HR=1.35, 1.98, 1.46, 95% confidence intervals as 1.02?1.79, 1.40?2.80, 1.13?1.89, P<0.05), and bilateral metal biliary stents, anti-tumor therapy were independent protective factors for the overall survival time of patients ( HR=0.68, 0.60, 95% confidence intervals as 0.53?0.89, 0.45?0.80, P<0.05). Conclusions:Endoscopic drainage with or without metal biliary stents' distal portion crossing the duodenal main papilla is safe and feasible for patients with malignant hilar bile duct obstruction. Bilateral metal biliary stents is an independent protective factor for the patency time of metal biliary stents. Age >60 years, disease type as hepatocellular carcinoma, preoperative serum total bilirubin >200 μmol/L are independent risk factors for the overall survival time of patients, and bilateral metal biliary stents, anti-tumor therapy are independent protective factors for the overall survival time of patients.

Factors affecting the clinical success rate of miniscrew implants for orthodontic treatment / 中国组织工程研究

BACKGROUND: During the orthodontic treatment, the results of related reports on potential risk factors affecting the clinical success rate of miniscrew implants are inconsistent. The influential factors that clinicians concern are not all included in this study, and the conclusions from animal experiments are difficult to apply to clinical practice directly. Therefore, what factors affect the clinical success rate of miniscrew implants need further thorough and systematic research. OBJECTIVE: To investigate the factors that influence the clinical success rate of miniscrew implants used as orthodontic anchorage. METHODS: A total of 114 patients with oral implants, including 42 males and 72 females, aged (19. 26±9. 19) years were included in this study. A total of 253 miniscrew implants were implanted as orthodontic anchorage. The following influential factors were included: Gender, age, vertical skeletal facial pattern, implant site, implant arch, soft tissue type at the implant site, oral hygiene status, diameter and length of the miniscrew implants, implantation method, implantation angle, stress loading timing and intensity, and clinical use. Logistic regression analysis was used to study the correlation between success rate and all variables. Analysis of variance was used to test the effect of each variable on clinical success rate. This trial protocol was approved by the Medical Ethics Committee of Sichuan University. RESULTS AND CONCLUSION: Among 253 successful miniscrew implants, the overall success rate was 88. 54% with an average loading period of 9. 5 months. The average loading period of the 29 failed miniscrew implants was 2. 3 months. The chi-square test, Fisher exact test and Logistic regression revealed that age, oral hygiene, vertical skeletal facial pattern, and implant site were significantly correlated with clinical success rate (P 0. 05). These results suggest that to minimize the failure of miniscrew implants, proper oral hygiene instruction and effective supervision should be given to patients, in particular to those young (< 12 years) high mandibular plane patients.

Long-term Short Implants Performance: Systematic Review and Meta-Analysis of the Essential Assessment Parameters

Lack of standard criteria in the outcome assessment makes it difficult to draw conclusions on the clinical performance of short implants and, under these circumstances, determine the reasons for implant failure. This study evaluated, through a systematic review of the literature and meta-analysis, the essential parameters required to assess the long-term clinical performance of short and extra-short implants. Electronic databases (Pubmed-MEDLINE, Cochrane Library Database, Embase, and Lilacs) were searched by two independent reviewers, without language limitation, to identify eligible papers. References from the selected articles were also reviewed. The review included clinical trials involving short dental implants placed in humans, published between January 2000 and March 2014, which described the parameters applied for outcome's measurements and provided data on survival rates. Thirteen methodologically acceptable studies were selected and 24 parameters were identified. The most frequent parameters assessed were the marginal bone loss and the cumulative implant survival rate, followed by implant failure rate and biological complications such as bleeding on probing and probing pocket depths. Only cumulative implant survival rate data allows meta-analysis revealing a positive effect size (from 0.052 (fixed) to 0.042 (random)), which means that short implant appears to be a successful treatment option. Mechanical complications and crown-to-implant (C/I) ratio measurement were also commonly described, however, considering the available evidence; no strong conclusions could be drawn since different methods were used to assess each parameter. By means of this literature review, a standard evaluation scheme is proposed, being helpful to regiment further investigations and comparisons on future studies.

A falta de critérios padronizados para a avaliação dos resultados faz com que seja difícil tirar conclusões sobre o desempenho clínico dos implantes curtos e, nestas circunstâncias, determinar as razões para o fracasso do implante. Este estudo avaliou, através de uma revisão sistemática da literatura, os parâmetros essenciais necessários para avaliar o desempenho clínico em longo prazo de implantes curtos e extra-curtos. Bases de dados eletrônicas (PubMed-MEDLINE, Base de dados da Biblioteca Cochrane, Embase e Lilacs) foram avaliadas por dois revisores independentes, sem limitação da linguagem, de modo a identificar artigos elegíveis. As referências dos artigos selecionados foram também analisadas. A revisão incluiu estudos clínicos, publicados entre janeiro de 2000 e março de 2014, envolvendo implantes dentais curtos, instalados em seres humanos, nos quais foram descritos os parâmetros utilizados para mensuração dos resultados e fornecidos dados sobre as taxas de sobrevivência. Treze estudos metodologicamente aceitáveis foram selecionados, sendo identificados 24 parâmetros. Os parâmetros avaliados com maior frequencia foram a perda óssea marginal e a taxa cumulativa de sobrevivência do implante, seguida pela taxa de falha dos implantes e complicações biológicas, tais como sangramento à sondagem e profundidade de sondagem. Apenas a taxa cumulativa de sobrevivência dos implantes permitiu a meta-análise revelando efeito positivo (variação de 0.052 (efeito fixo) até 0.042 (efeito aleatório)), demonstrando que os implantes curtos parecem ser uma opção de tratamento bem sucedida. Complicações mecânicas e a mensuração da proporção coroa-implante foram também referidas, entretanto, considerando-se as evidências disponíveis, não se pode chegar a fortes conclusões, pois diferentes métodos foram utilizados para avaliar cada parâmetro. Por meio desta revisão da literatura, um esquema padronizado de avaliação é proposto, sendo útil para arregimentar ...

Postes colados: estudio clínico retrospectivo de 44 años en clínica privada especializada / Cast posts: a forty-four year retrospective clinical study in a specialized private practice

El objetivo de este estudio fue examinar el resultado clínico longitudinal de dientes endodónticamente tratados, rehabilitados con postes colados y una restauración coronaria, durante 44 años. Materiales y Métodos. En 130 pacientes seleccionados al azar, 95 presentaron 297 dientes rehabilitados con un poste colado y una restauración coronaria. El criterio de éxito fue que el diente rehabilitado permaneciera funcional sin patología clínica ni radiográfica. Resultados: Doscientos sesenta y ocho (90%) estaban en función y 29 (10%) habían fracasado. El Indice Kappa de Cohen, fue de 0.78 - 1. Conclusiones. El éxito clínico fue de 90%. La sobrevida media observada de los dientes estudiados fue de 19 años. La tasa de fracaso fue de 10%, siendo la fractura dentaria la falla más prevalente (5% de todos los dientes restaurados)...

The aim of this study was to examine the longitudinal clinical result of the use of cast posts and cores and crown restorations in endodontically treated teeth over a 44-year period. Materials and methods. Out of 130 randomly selected patients, 95 had had 297 teeth rehabilitated with cast posts and cores and crown restorations. The endodontic rehabilitation was considered successful when the tooth remained functional with no clinical or radiographic pathology. Results. The success rate was 90% (268) and the failure rate 10% (29). Cohen’s Kappa index ranged between 0.78 and 1. Conclusions. In this 44-year retrospective study, the clinical success rate was 90%. The mean survival time of the studied teeth was 19 years. The failure rate was 10%; tooth fractures were the most prevalent failures (5% of all restored teeth)...

Fluoroscopy-Guided Lumbar Drainage of Cerebrospinal Fluid for Patients in Whom a Blind Beside Approach Is Difficult

OBJECTIVE: To evaluate the rates of technical success, clinical success, and complications of fluoroscopy-guided lumbar cerebrospinal fluid drainage. MATERIALS AND METHODS: This retrospective study was approved by the Institutional Review Board of our hospital, and informed consent was waived. Ninety-six procedures on 60 consecutive patients performed July 2008 to December 2013 were evaluated. The patients were referred for the fluoroscopy-guided procedure due to failed attempts at a bedside approach, a history of lumbar surgery, difficulty cooperating, or obesity. Fluoroscopy-guided lumbar drainage procedures were performed in the lateral decubitus position with a midline puncture of L3/4 in the interspinous space. The catheter tip was positioned at the T12/L1 level, and the catheter was visualized on contrast agent-aided fluoroscopy. A standard angiography system with a rotatable C-arm was used. The definitions of technical success, clinical success, and complications were defined prior to the study. RESULTS: The technical and clinical success rates were 99.0% (95/96) and 89.6% (86/96), respectively. The mean hospital stay for an external lumbar drain was 4.84 days. Nine cases of minor complications and eight major complications were observed, including seven cases of meningitis, and one retained catheter requiring surgical removal. CONCLUSION: Fluoroscopy-guided external lumbar drainage is a technically reliable procedure in difficult patients with failed attempts at a bedside procedure, history of lumbar surgery, difficulties in cooperation, or obesity.

Evaluación clínica y radiográfica de 30 implantes dentales colocados en un servicio odontológico de posgrado / Clinical and Radiographic Evaluation of 30 Dental Implants placed in a Postgraduate Dental Service

Resumen Introducción y objetivo: Existen reportes de complicaciones que hacen que el implante fracase, esto justifica la evaluación permanente de los mismos. Se buscó evaluar clínica y radiográficamente los implantes colocados en un servicio odontológico de posgrado para proponer un protocolo de evaluación y monitoreo. Materiales y métodos: Este estudio descriptivo evaluó 30 implantes de 16 pacientes. Los antecedentes quirúrgicos se tomaron de la historia clínica. Se valoraron criterios primarios como dolor, exudado, supuración, movilidad y profundidad del surco y criterios secundarios como los índices de placa y de sangrado. Se analizaron radiografías peri apicales milimetradas para identificar la presencia de anormalidades y la pérdida ósea marginal. Resultados: Diecinueve implantes cumplieron con los criterios de éxito Ahlqvist. Clínicamente, 22 implantes presentaron alguna alteración en los criterios de normalidad evaluados. En los criterios primarios se encontró presencia de signos inflamatorios en 11 implantes. El índice de higiene oral registró un porcentaje de 33% de placa en 2 implantes de un mismo paciente. El índice de sangrado registró un valor de 1 en 22 implantes. No se observó movilidad en toda la muestra, ni imágenes radio-lúcidas alrededor de los implantes. Conclusión: Diecinueve de los implantes analizados registraron "éxito clínico" según los criterios de Ahlqvist. Radiográficamente 28 implantes registraron condiciones dentro de parámetros normales. Los protocolos para evaluar los implantes deben considerar la historia médica y quirúrgica, criterios primarios y secundarios, la pérdida ósea marginal y la calidad del hueso alrededor del implante.

Introduction and objective: There are reports of complications that can cause implants to fail. This justifies long term evaluation of implants. The purpose of this study was to evaluate clinically and radiographically implants placed in a postgraduate dental service in order propose a protocol for evaluating and monitoring. Materials and methods: This descriptive study evaluated 30 implants on 16 patients. The surgical records were obtained from the patient's medical history. Primary criteria such as pain, exudate, suppuration, mobility and probing depth were assessed. Secondary criteria such as plaque and probing depth index were also assessed. Radiological analysis was performed to identify the presence of abnormalities and the average marginal bone loss. Results: 19 of the implants evaluated met the success criteria by Ahlqvist et al. Clinically, 22 implants showed some changes in the criteria of abnormality assessed in this study. Regarding the primary criteria, presence of inflammatory signs were found in 11 implants. Oral hygiene index showed a rate of 8% in 4 implants in the same patient, and 33% of plaque in 2 implants in the same patient. The bleeding index showed a value of 1 in 22 implants. Mobility was not observed in the sample and no radiolucent images around the implants. Conclusions: Nineteen of the examined implants were considered clinically successful according to the criteria by Ahlqvist et al. Radiographically, 28 implants showed conditions within normal parameters. Protocols for evaluating dental implants should consider the medical and surgical history, primary and secondary criteria , marginal bone loss and bone quality around the implants.

Retrospective Study of Oral Antifungal Agents in the Treatment of Toenail Onychomycosis / 대한의진균학회지

BACKGROUND: Clinical success rate is determined by patients compliance which depends on treatment method and period. Retrospective study to clinical success rate may give the information to promote compliance with oral medications for onychomycosis. OBJECTIVE: The purpose of this study was to evaluate clinical success rate in the different treatment group. METHOD: For the retrospective study, 618 patients diagnosed clinically and mycologically as having onychomycosis were evaluated for the cure rate and drop-out rate. RESULTS: The drop-out rate was 31.5% in itraconazole monthly pulse group, 74.3% in itraconazole daily continuous group, 77.5% in terbinafine daily continuous group and 97.8% in fluconazole weekly pulse group. Therefore the success rate was 68.5% in itraconazole monthly pulse group, 25.7% in itraconazole daily continuous group, 22.5% in terbinafine daily continuous group and 2.2% in fluconazole weekly pulse group. The drop-out rate was high in the first period of treatment schedule in most of treatment groups except itraconazole monthly pulse and daily continuous groups. CONCLUSION: We concluded that the treatment duration and method are the critical factor to treat tonail onychomycosis relating in determining patients' preference for treatment schedules.

Retrospective Study of Oral Antifungal Agents in the Treatment of Toenail Onychomycosis / 대한의진균학회지

BACKGROUND: Clinical success rate is determined by patients compliance which depends on treatment method and period. Retrospective study to clinical success rate may give the information to promote compliance with oral medications for onychomycosis. OBJECTIVE: The purpose of this study was to evaluate clinical success rate in the different treatment group. METHOD: For the retrospective study, 618 patients diagnosed clinically and mycologically as having onychomycosis were evaluated for the cure rate and drop-out rate. RESULTS: The drop-out rate was 31.5% in itraconazole monthly pulse group, 74.3% in itraconazole daily continuous group, 77.5% in terbinafine daily continuous group and 97.8% in fluconazole weekly pulse group. Therefore the success rate was 68.5% in itraconazole monthly pulse group, 25.7% in itraconazole daily continuous group, 22.5% in terbinafine daily continuous group and 2.2% in fluconazole weekly pulse group. The drop-out rate was high in the first period of treatment schedule in most of treatment groups except itraconazole monthly pulse and daily continuous groups. CONCLUSION: We concluded that the treatment duration and method are the critical factor to treat tonail onychomycosis relating in determining patients' preference for treatment schedules.